Magnetic Group Signaling (MGS®) standardizes NMR systems and sample processing to ensure reproducible results on different NMR instruments.
Advanced. Automated. Affordable. Mastering Metabolite Networks for Real-Time Precision Medicine.
AXINON® is the first modular software-based system providing hardware, operating system, MGS® processor and individual test applications.
Cancer is among the leading causes of death worldwide. Approximately 38 % of men and women will be diagnosed with cancer at some point during their lifetimes (based on 2013 – 2015 data1). Cancer can occur in any organ and in any cell type and the variability in clinical presentation makes early diagnosis difficult. Common cancers with established benefit of early diagnosis but for which there are no sensitive or specific tests are prostate, bladder and liver cancer1.
Expensive imaging procedures are routinely required in clinical practice for diagnosis or to monitor disease progression of these cancers. To date, there are no accurate biomarkers for either diagnosis or disease progression monitoring for prostate, bladder or liver cancer. Often the poor accuracy of existing cancer biomarkers confuses clinical decision making rather than assist in disease diagnosis or monitoring.
1 Bray F, et al.. Global Cancer Statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, in press.
(in dev.) numares’ mission in oncology is to develop IVD tests that improve the care and management of patients with prostate, bladder and hepatic cellular cancer. This goal is achieved by developing and using metabolite constellations of cancer specific serum or urine biomarkers by NMR.
By means of artificial intelligence and biostatistical modelling (machine learning), the metabolite constellations are evaluated in clinical studies for clinical correlation. The numares methodology is unique and powerful with a proven track record for identification of metabolite biomarkers, clinical validation and commercialization.
In Oncology, our biomarker discovery pipeline will provide a new powerful tool in developing multi-parametric tests for cancer diagnosis, cancer progression monitoring and to evaluate therapeutic efficacy.
More information on the AXINON® IVD System
Our oncology biomarker development pipeline and all future oncology tests will be available for the AXINON® IVD System which produces high-quality, standardized NMR spectra based on numares’ Magnetic Group Signaling (MGS®) technology.
The combination of MGS® technology with the AXINON® IVD System allows for test-specific spectral analysis with highly-reproducible results. The test system is easy to use with one-step sample preparation with ready-to-use reagents requiring minimal operator interaction. The test system is fast and efficient with automation capabilities allowing short hands-on-time and high walk-away capability.
To date, more than 2 million tests have been performed worldwide based on numares’ technology.